Tuesday 3 April 2012

Why hormones for menopause are linked to breast cancer - update 78


One would have thought that by now everyone would be on the same page when it comes to the use of hormones for menopause, whether those hormones are to be used for amelioration of symptoms – hot flushes, sleep disturbances, mood changes, etc – or whether the hormones are pushed for lowering the risk of certain medical conditions that rise dramatically in the senior years – osteoporosis, dementia, etc.

And that page that you’d think we’re all on is simply this: while hormone “therapy” might improve certain menopausal symptoms, particularly hot flushes, and while their use might lower the risks of certain health problems later-in-life such as osteoporosis and colon cancer, those benefits are more than offset in most women by the fact that hormones clearly raise the risk of breast cancer, and the longer that women use hormones and the higher the dose they use, the greater that risk of breast cancer.

But over the last few years, there’s been a strong pushback in this no-hormones-for-you (shades of the Soup Nazi) attitude from many doctors with the argument that 1) hormones are the only real treatment for severe menopausal symptoms, and 2) the threat of breast cancer from the use of hormones has been largely over-blown, and 3) the use of estrogen alone without progesterone is not likely to raise the risk of breast cancer.

So it’s important to note that in the latest update from the famous and ongoing Nurses’ Health Study, the researchers conclude that the use of any hormones at all raises the risk of breast cancer, although the use of estrogen alone raised that risk only slightly while combined estrogen and progesterone raised the risk substantially if used for over 10 years.

Bottom line: all medications carry risks and you must always ask yourself it the benefit – especially when that benefit only applies to symptom relief – is worth those risks.