Monday 25 March 2013

False positive test results



One of the most difficult messages to get across to an average health-conscious person, especially an aging one, is that screening tests are not necessarily always benign.

Or putting that in another fashion: while not dangerous in themselves, lots of screening tests can – and do - result in ultimate harm to the person who had one.

That comes mainly from “false positive” results, which occur much more often than many people realize, and certainly much more often than doctors are generally willing to admit.

The harm from false positive results in screening tests comes from two sources: potential physical harm (biopsies are surgical interventions, and there is no such thing as risk-free surgery) and equally important, from psychological effects, although that side of things is often neglected or rejected as a minor concern., which it decidedly is not for many people.

That came home in a pretty stark fashion this week from a report in the March/April issue of The Annals of Family Medicine in which Danish researchers concluded that a small but substantial number of women who receive false positive reports from a mammogram are adversely affected by psychological problems for up to 3 years following that report.

Now it may only be a small number of women who are affected in that way, but given how common mammograms are and given how often they result in false positives (another report this week estimated that in some young women with dense breasts, the false positive rate for mammography can be as high as a whopping 60 %), the total number of women who suffer these adverse consequences is consequently huge, and we really don’t know that ultimate cost.

Now, it has to be stressed that on the very important other hand, mammograms do save some lives (although the number of lives saved by mammography is a constant topic of debate among the experts), so this should not dissuade anyone from getting a mammogram: it should just be something that every woman adds into the mix of things she has to consider before automatically getting such a test.

And what is true of mammography is also true for many (most?) other screening tests as well.