Wednesday 9 July 2014

Test for Alzheimers disease

When is a medical “breakthrough” never a  real breakthrough?

Nearly always.

Simple 2 reasons: first, these days medical researchers hype their data beyond all reason, and second, very, very, very few medical reporters have absolutely any idea at all about how to interpret what they are fed by PR departments, on top of which hardly any of them – us, really – know the first thing about statistics.

Great example: a study out this week heavily hyped by British reporters and headlines (researchers were British) about a “breakthrough” blood test for Alzheimer’s in which the researchers claim to have come up with a test that can determine with “up to 87 %” accuracy which of the many people who have mild cognitive impairment (MCI) will actually go on to get AD over the next 10 years.

Only trouble is, when people better at this than me parsed the data, they concluded that the real predictability of this test as to whether any particular individual may develop AD is roughly 50 % (in fact, it can be as low as 47 %).

Hey, I don’t have to know anything at all about you and I can predict with 50 % accuracy whether you – or I – will develop AD simply by guessing “yes” or “no”.

Doubt that that would qualify as a breakthrough, though.